Pramocaine hydrochloride (Standard)
Pramocaine (Pramoxine) hydrochloride (Standard) is the analytical standard of Pramocaine hydrochloride (HY-B1319). This product is intended for research and analytical applications. Pramocaine hydrochloride is a topical surface anesthetic and antipruritic agent. Pramocaine hydrochloride reversibly inhibits voltage-gated sodium channel, reduces transmembrane permeability of sodium ions, stabilizes cell membranes, prevents depolarization, blocks action potential conduction, and inhibits peripheral slow C-fiber pathways associated with pain, pruritus and thermoception. Pramocaine hydrochloride can be used in research related to chronic pruritus, renal pruritus, atopic dermatitis, xerotic pruritus, uremic pruritus, and cutaneous hyperalgesia/pain.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 637-58-1
- Formula: C17H28ClNO3
- Molecular Weight:329.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 637-58-1
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Molecular Weight 329.86
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Formula C17H28ClNO3
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SMILES
CCCCOC1=CC=C(OCCCN2CCOCC2)C=C1.[H]Cl
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Synonyms
Pramoxine hydrochloride (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1].
Agarwal A, et al. Topical Pramoxine in Chronic Pruritus: Where do We Stand? Indian J Dermatol. 2021 Sep-Oct;66(5):576.
[Content Brief]
[2]. Chou AK, et al. Intrathecal pramoxine causes long-lasting spinal sensory and motor block in rats. The Journal of pharmacy and pharmacology. 2018 Apr;70(4):543-549. [Content Brief]
[3]. Chou AK, et al. Skin nociceptive block with pramoxine delivery by subcutaneous injection in rats. Pharmacological reports : PR. 2018 Dec;70(6):1180-1184. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pramocaine hydrochloride (Standard) Related Classifications
HY-B1319R Related Classifications
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- Pramocaine hydrochloride (Standard)
- 637-58-1
- Pramoxine hydrochloride (Standard)
- Reference Standards
- Sodium Channel
- nociception
- chronic pruritus
- motor function
- renal pruritus
- peripheral slow C fiber pathways
- atopic dermatitis
- proprioception
- uremic pruritus
- rats
- voltage-gated sodium channels
- Inhibitor
- inhibitor
- inhibit