Prednisone-d₈  (Synonyms: Dehydrocortisone-d₈)

Prednisone-d₈ is the deuterium labeled Prednisone. Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

366.48

C₂₁H₁₈D₈O₅

53-03-2

Solid

White to off-white

C[C@@]1(C2([2H])[2H])[C@](C(C([2H])([2H])O)=O)(O)CC[C@@]1([H])[C@]3([H])C[C@@]([2H])([H])C4=C([2H])C(C([2H])=C[C@]4(C)[C@@]3([2H])C2=O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. RIEMER AD. Application of the newer corticosteroids to augment diuresis in congestive heart failure. Am J Cardiol. 1958 Apr;1(4):488-96.  [Content Brief]

  [3]. Zhang H, et al. Prednisone adding to usual care treatment for refractory decompensated congestive heart failure. Int Heart J. 2008 Sep;49(5):587-95.  [Content Brief]