Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports

  • J Pept Sci. 2000 Oct;6(10):534-8. doi: 10.1002/1099-1387(200010)6:10<534::AID-PSC288>3.0.CO;2-3.
C T Bui  1 ,  F Ercole ,  Y Pham ,  R Campbell ,  F A Rasoul ,  N J Maeji ,  N J Ede
Affiliations
  • 1. Mimotopes Pty. Ltd., Clayton, Victoria, Australia.
PMID: 11071267 DOI: 10.1002/1099-1387(200010)6:10<534::AID-PSC288>3.0.CO;2-3
Abstract

A replacement of the acetic acid moiety by valeric acid within the 4-hydroxymethylphenoxyacetic acid (HMP) linker (Sheppard RC, Williams BJ. Acid-labile resin linkage agents for use in solid phase peptide synthesis. Int. J. Peptide Protein Res. 1982; 20: 451-454) significantly improved its performance in terms of loading capacity, yield and purity of the final products. The results indicated the spacer-linker combination and type of solid supports are important factors for solid-phase synthesis.

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