Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl
- Biochem J. 2003 Feb 15;370(Pt 1):29-34. doi: 10.1042/BJ20021539.
Affiliations
- 1. Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S-75124, Sweden.
PMID: 12475393
DOI: 10.1042/BJ20021539
Abstract
The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin Ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.