Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors

  • Bioorg Med Chem Lett. 2004 May 17;14(10):2499-503. doi: 10.1016/j.bmcl.2004.03.001.
Hyun-Suk Lim  1 ,  Jeong-Ju Park ,  Kwangseok Ko ,  Mee-Hyun Lee ,  Sung-Kee Chung
Affiliations
  • 1. Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31, Hyoja-Dong, Nam-gu, Pohang 790-784, South Korea.
PMID: 15109640 DOI: 10.1016/j.bmcl.2004.03.001
Abstract

Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P(1), syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.

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