The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids

  • Chem Commun (Camb). 2005 Nov 21;(43):5438-40. doi: 10.1039/b510707e.
Biswadip Banerji  1 ,  Ana Conejo-Garcia ,  Luke A McNeill ,  Michael A McDonough ,  Matthew R G Buck ,  Kirsty S Hewitson ,  Neil J Oldham ,  Christopher J Schofield
Affiliations
  • 1. Department of Chemistry and Oxford Centre for Molecular Sciences, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UKOX1 3TA.
PMID: 16261239 DOI: 10.1039/b510707e
Abstract

Cyclic beta-oxocarboxylic acids inhibit factor inhibiting hypoxia-inducible factor via ligation to the active site iron.

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