Cucurbitane glycosides from unripe fruits of Lo Han Kuo (Siraitia grosvenori)

  • Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1425-8. doi: 10.1248/cpb.54.1425.
Dianpeng Li  1 ,  Tsuyoshi Ikeda ,  Nanae Matsuoka ,  Toshihiro Nohara ,  Hourui Zhang ,  Tatsunori Sakamoto ,  Gen-Ichiro Nonaka
Affiliations
  • 1. Faculty of Medical and Pharmaceutical Science, Kumamoto University, Kumamoto, Japan.
PMID: 17015982 DOI: 10.1248/cpb.54.1425
Abstract

From the unripe fruits of Lo Han Kuo (Siraitia grosvenori), a Chinese medicinal plant, two new cucurbitane triterpene glycosides, 20-hydroxy-11-oxomogroside IA(1) (1) and 11-oxomogroside IIE (2), were isolated along with five known cucurbitane glycosides, 11-oxomogroside IA(1) (3), mogroside IIE (4), mogroside III (5), mogroside IVA (6), and mogroside V (7), and two flavonoid glycosides, kaempferol 7-O-alpha-L-rhamnopyranoside (8) and kaempferol 3,7-di-O-alpha-L-rhamnopyranoside (9). Their structures were determined on the basis of detailed analyses of 1D, 2D-NMR spectroscopic methods and by comparing with literature values. This paper describes the first investigation of unripe bitter Lo Han Kuo fruits.

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