Triterpene saponins from clematis mandshurica

  • J Nat Prod. 2006 Nov;69(11):1591-5. doi: 10.1021/np060287z.
Shepo Shi  1 ,  Dan Jiang ,  Caixia Dong ,  Pengfei Tu
Affiliations
  • 1. School of Pharmaceutical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100083, People's Republic of China.
PMID: 17125227 DOI: 10.1021/np060287z
Abstract

Four new triterpene saponins, clematomandshurica saponins A-D (1-4), together with three known saponins (5-7) have been isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of their spectroscopic evidence and hydrolysis. Clematomandshurica saponins A and B showed significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.66 and 2.58 microM, respectively).

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