Mycophenolic acid as a latent agonist of PPARgamma

  • Bioorg Med Chem Lett. 2007 Sep 1;17(17):4767-70. doi: 10.1016/j.bmcl.2007.06.059.
Makoto Ubukata  1 ,  Hitomi Takamori ,  Misaki Ohashi ,  Shinya Mitsuhashi ,  Kaoru Yamashita ,  Tomohisa Asada ,  Noriyuki Nakajima ,  Nobuyasu Matsuura ,  Mie Tsuruga ,  Keiko Taki ,  Junji Magae
Affiliations
  • 1. Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Sapporo, Japan. [email protected]
PMID: 17618115 DOI: 10.1016/j.bmcl.2007.06.059
Abstract

Mycophenolic acid (MPA), known as an inhibitor of inosine monophosphate dehydrogenase (IMPDH), was found to inhibit the differentiation of 3T3-L1 pre-adipocytes into mature adipocytes. Although the effect of MPA was attributed to inhibition of IMPDH, we uncovered a hidden biological property of MPA as an agonist of peroxisome proliferator activated receptor gamma (PPARgamma).

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