New polyhydroxylated furostanol saponins with inhibitory action against NO production from Tupistra chinensis rhizomes

  • Molecules. 2007 Aug 23;12(8):2029-37. doi: 10.3390/12082029.
Lan-Lan Xu  1 ,  Kun Zou ,  Jun-Zhi Wang ,  Jun Wu ,  Yuan Zhou ,  Fei-Jun Dan ,  Jing Yang
Affiliations
  • 1. Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, PR China. [email protected]
PMID: 17960103 DOI: 10.3390/12082029
Abstract

Two furostanol saponins were obtained from the rhizomes of Tupistra chinensis Bak. Their structures were determined as 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,7alpha,22xi,26-octaol-6-one-26-O-beta-D-glucopyranoside (1) and 5beta-furost-delta(25(27))-en-1beta,2beta,3beta,4beta,5beta,6beta,7alpha,22xi,26-nonaol-26-O-beta-D-glucopyranoside (2), on the basis of chemical and spectroscopic evidence. Both compounds displayed marked inhibitory action against NO production in rat abdomen macrophages induced by lipopolysaccharide (LPS) at 40 microg/mL.

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