Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors

  • Bioorg Med Chem Lett. 2008 Jan 1;18(1):39-43. doi: 10.1016/j.bmcl.2007.11.016.
Kiev S Ly  1 ,  Michael A Letavic ,  John M Keith ,  Jennifer M Miller ,  Emily M Stocking ,  Ann J Barbier ,  Pascal Bonaventure ,  Brian Lord ,  Xiaohui Jiang ,  Jamin D Boggs ,  Lisa Dvorak ,  Kirsten L Miller ,  Diane Nepomuceno ,  Sandy J Wilson ,  Nicholas I Carruthers
Affiliations
  • 1. Johnson & Johnson Pharmaceutical Research & Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA.
PMID: 18060777 DOI: 10.1016/j.bmcl.2007.11.016
Abstract

The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H3 ligands and serotonin reuptake inhibitors.

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