Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells

  • Fitoterapia. 2009 Jun;80(4):219-22. doi: 10.1016/j.fitote.2009.01.011.
Ying-Kun Qiu  1 ,  De-Qiang Dou ,  Li-Ping Cai ,  Hai-Ping Jiang ,  Ting-Guo Kang ,  Bing-You Yang ,  Hai-Xue Kuang ,  Michael Zc Li
Affiliations
  • 1. College of Pharmacy, Liaoning University of Traditional Chinese Medicine, DD Port, Dalian Economic and Technical Development Zone, 116600 Dalian, China.
PMID: 19535014 DOI: 10.1016/j.fitote.2009.01.011
Abstract

A new compound, named quinquefoloside-L(c) (1), together with nine known compounds, was isolated from leaves of Panax quinquefolium, and its structure was elucidated as 3beta,12beta, 20S-trihydroxy-25-methoxydammar-23-ene 3-O-beta-D-glucopyranosyl (1-->2)beta-D-glucopyranosyl-20-O-beta-D-xylopyanosyl (1-->6) beta-D-glucopyranoside (1), on the basis of MS, 1D-and 2D-NMR experiments as well as by chemical degradation. The cytotoxicity of these compounds against human breast Cancer MCF-7 cell line was also tested by MTT method.

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