Four new cytotoxic oligosaccharidic derivatives of 12-oleanene from Lysimachia heterogenea Klatt

  • Bioorg Med Chem Lett. 2009 Dec 1;19(23):6515-8. doi: 10.1016/j.bmcl.2009.10.056.
Xin-an Huang  1 ,  Yong-ju Liang ,  Xiao-ling Cai ,  Xiao-quan Feng ,  Chuan-hai Zhang ,  Li-wu Fu ,  Wen-di Deng
Affiliations
  • 1. Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. [email protected]
PMID: 19875285 DOI: 10.1016/j.bmcl.2009.10.056
Abstract

Cytotoxicity-guided phytochemical analysis on the extract of Lysimachia heterogenea Klatt led to the isolation of 3beta,16beta-12-oleanene-3,16,23,28-tetrol (1) and its four new oligosaccharidic derivatives heterogenosides A, B, C, and D (2-5). Their structural elucidation was mainly based on NMR and mass spectral data. The time course experimental results indicated that unlike the likely lysis activity of heterogenosides B-D, heterogenoside A showed a significantly time-dependent cytotoxicity.

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