Can animal models of disease reliably inform human studies?

  • PLoS Med. 2010 Mar 30;7(3):e1000245. doi: 10.1371/journal.pmed.1000245.
H Bart van der Worp  1 ,  David W Howells ,  Emily S Sena ,  Michelle J Porritt ,  Sarah Rewell ,  Victoria O'Collins ,  Malcolm R Macleod
Affiliations
  • 1. Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands. [email protected]
PMID: 20361020 DOI: 10.1371/journal.pmed.1000245
Abstract

H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials.