Heronapyrroles A-C: farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp

  • Org Lett. 2010 Nov 19;12(22):5158-61. doi: 10.1021/ol102162d.
Ritesh Raju  1 ,  Andrew M Piggott ,  Leticia X Barrientos Diaz ,  Zeinab Khalil ,  Robert J Capon
Affiliations
  • 1. Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
PMID: 20949971 DOI: 10.1021/ol102162d
Abstract

Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0423) isolated from beach sand off Heron Island, Australia, yielded three new members of the rare pyrroloterpene biosynthetic structure class. Identified by detailed spectroscopic analysis as the first reported examples of naturally occurring 2-nitropyrroles, heronapyrroles A-C (1-3) displayed promising biological activity-with low to submicromolar IC(50) activity against Gram-positive bacteria but no cytotoxicity toward mammalian cell lines.

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