Daphnane- and tigliane-type diterpenoid esters and orthoesters from Pimelea elongata

  • J Nat Prod. 2010 Nov 29;73(11):1907-13. doi: 10.1021/np1005746.
Patricia Y Hayes  1 ,  Sharon Chow ,  Michael J Somerville ,  Mary T Fletcher ,  James J De Voss
Affiliations
  • 1. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.
PMID: 21049973 DOI: 10.1021/np1005746
Abstract

Investigation of Pimelea elongata ("Lakebed Pimelea") afforded 18 tigliane- and daphnane-type diterpenes (1-18). Eight of these were new compounds: four (1-3, 5) tigliane esters and four (7, 8, 10, 11) daphnane orthoesters. The 10 known compounds were 12-O-decanoylphorbol-13-acetate (4), P. simplex subtoxin B (6), wikstroelide E (9), pimelotides A and B (12, 13), gnidiglaucin (14), simplexin (15), huratoxin (16), kirkinine D (17), and 12-β-acetoxyhuratoxin (18). The structures and relative configurations of the new compounds were determined by 1D and 2D NMR spectroscopic studies in combination with MS analyses.

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