CD73 promotes tumor growth and metastasis

  • Oncoimmunology. 2012 Jan 1;1(1):67-70. doi: 10.4161/onci.1.1.18068.
Bin Zhang  1
Affiliations
  • 1. Department of Medicine; Cancer Therapy & Research Center; University of Texas Health Sciences Center; San Antonio, TX USA.
PMID: 22720214 DOI: 10.4161/onci.1.1.18068
Abstract

Our recent data and that of Others demonstrate that both tumor and host CD73-generated Adenosine promote tumor growth and metastasis in a multifactorial manner. Results with small molecule inhibitors or Monoclonal Antibodies against CD73 in multiple tumor models suggest that CD73 is a previously unappreciated important target for effective Cancer therapy.

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