Cucurbitane-type triterpenoids from the fruit pulp of Momordica charantia

  • Nat Prod Commun. 2012 Dec;7(12):1575-8.
Yun-Wen Liao  1 ,  Chiy-Rong Chen ,  Yueh-Hsiung Kuo ,  Jue-Liang Hsu ,  Wen-Ling Shih ,  Hsueh-Ling Cheng ,  Tzou-Chi Huang ,  Chi-I Chang
Affiliations
  • 1. Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
PMID: 23413554
Abstract

Three new cucurbitane-type triterpenoids, 5beta,19-epoxy-23(R)-methoxycucurbita-6,24-dien-3beta-ol (1), 5beta,19-epoxy-23(S)-methoxycucurbita-6,24-dien-3beta-ol (2), and 3beta-hydroxy-23(R)-methoxycucurbita-6,24-dien-5beta,19-olide (3), were isolated from the fruit pulp of Momordica charantia. Their structures were established on the basis of extensive NMR (1H, 13C, COSY, HMQC, HMBC, and NOESY) and EI-MS studies. Compound 1 exhibited cytotoxic activity against the SK-Hep 1 cell line.

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