New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia

  • Bioorg Med Chem Lett. 2013 Jul 1;23(13):3879-83. doi: 10.1016/j.bmcl.2013.04.072.
Bei Jiang  1 ,  Wen-Jing Wang ,  Man-Ping Li ,  Xiao-Jun Huang ,  Feng Huang ,  Hao Gao ,  Ping-Hua Sun ,  Ming-Fang He ,  Zheng-Jin Jiang ,  Xiao-Qi Zhang ,  Wen-Cai Ye
Affiliations
  • 1. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, PR China.
PMID: 23711917 DOI: 10.1016/j.bmcl.2013.04.072
Abstract

The fruits of Alpinia oxyphylla are used as healthcare products for the protection on neurons and prevention of dementia. Two new noreudesmane sesquiterpenoids, (5R,7S,10S)-5-hydroxy-13-noreudesma-3-en-2,11-dione (1) and (10R)-13-noreudesma-4,6-dien-3,11-dione (2), and a new eudesmane sesquiterpenoid, (5S,8R,10R)-2-oxoeudesma-3,7(11)-dien-12,8-olide (3), as well as 12 known sesquiterpenoids, were isolated from the fruits of A. oxyphylla. The structures of the new compounds (1-3) were elucidated on the basis of spectroscopic data and circular dichroism experiments. All isolates were evaluated their neuroprotective potential by inhibitory assay on nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced mouse microglia BV-2 cells.

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