Cattienoids A-C, three novel steroids from the mushroom Tomophagus cattienensis

  • Fitoterapia. 2013 Dec:91:125-127. doi: 10.1016/j.fitote.2013.08.020.
Bui Thi Thu Hien  1 ,  Le Thi Phuong Hoa  2 ,  Le Xuan Tham  3 ,  Dang Ngoc Quang  4
Affiliations
  • 1. Faculty of Chemistry, Hanoi National University of Education, 136 XuanThuy Road, CauGiay, Hanoi, Viet Nam.
  • 2. Faculty of Biology, Hanoi National University of Education, 136 XuanThuy Road, CauGiay, Hanoi, Viet Nam.
  • 3. Department of Science & Technology, Lam dong, Viet Nam.
  • 4. Faculty of Chemistry, Hanoi National University of Education, 136 XuanThuy Road, CauGiay, Hanoi, Viet Nam. Electronic address: [email protected].
PMID: 24001711 DOI: 10.1016/j.fitote.2013.08.020
Abstract

Three novel Steroids (1-3), named cattienoids A-C together with schisanlactone A (4), were isolated from fruiting bodies of Tomophagus cattienensis (Ganodermataceae)-a new mushroom recently collected from Cattien National Park, in Viet Nam. They possess an unusual seven membered lactone ring, derived from lanostane-type triterpenoids. Their structures were determined by spectroscopic methods. In addition, compounds 2 and 4 showed cytotoxicity against KB (a human epidermal carcinoma) cells with their IC50 values of 91.2 and 63.3 μM, respectively. These compounds have neither antimicrobial activity nor inhibition of the Tyrosinase.

Keywords
Anticancer; Steroid; Tomophagus cattienensis; Tyrosinase.
Products