Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L

  • Bioorg Med Chem Lett. 2016 Jun 15;26(12):2788-2794. doi: 10.1016/j.bmcl.2016.04.066.
Manh Tuan Ha  1 ,  Manh Hung Tran  2 ,  Kim Jeong Ah  3 ,  Kyung-Jin Jo  4 ,  Jaewang Kim  4 ,  Wook Dong Kim  5 ,  Woo Jae Cheon  5 ,  Mi Hee Woo  2 ,  Sung Ho Ryu  4 ,  Byung Sun Min  6
Affiliations
  • 1. College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay District, Hanoi, Vietnam.
  • 2. College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
  • 3. College of Pharmacy, Kyungpook National University, Daegu 702-701, Republic of Korea.
  • 4. Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
  • 5. Gyeongsanbuk-do Forest & Environment Research Institute, Gyeongju 780-936, Republic of Korea.
  • 6. College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea. Electronic address: [email protected].
PMID: 27156775 DOI: 10.1016/j.bmcl.2016.04.066
Abstract

Detailed phytochemical investigation from the root bark of Morus alba resulted in the isolation of eleven new compounds, including seven 2-arylbenzofuran derivatives (morusalfurans A-G), three Flavonoids (morusalnols A-C), and one geranylated stilbene (morusibene A), as well as 22 known compounds. The structures of the identified compounds were elucidated based on a comprehensive analysis of spectroscopic data and Mosher's method. Compounds 2, 3, 6-8, 11, 23, 24, and 29 showed potent inhibition of PL in comparison with the positive control treatment (orlistat, IC50=0.012μM), with IC50 values ranging from 0.09 to 0.92μM.

Keywords
2-Arylbenzofuran; Geranylated stilbene; Moraceae; Morus alba; Pancreatic lipase.
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