Triterpene tetraglycosides from the sea cucumber Stichopus horrens

  • Nat Prod Res. 2018 May;32(9):1039-1043. doi: 10.1080/14786419.2017.1378206.
Le Thi Vien  1 ,  Le Hoang  1  2 ,  Tran Thi Hong Hanh  1 ,  Nguyen Van Thanh  1 ,  Nguyen Xuan Cuong  1  2 ,  Nguyen Hoai Nam  1 ,  Do Cong Thung  1  3 ,  Phan Van Kiem  1 ,  Chau Van Minh  1
Affiliations
  • 1. a Institute of Marine Biochemistry (IMBC) , Vietnam Academy of Science and Technology (VAST) , Hanoi , Vietnam.
  • 2. b Graduate University of Science and Technology, VAST , Hanoi , Vietnam.
  • 3. c Institute of Marine Environment and Resources (IMER) , VAST , Haiphong , Vietnam.
PMID: 28934865 DOI: 10.1080/14786419.2017.1378206
Abstract

Using various chromatographic separations, three triterpene tetraglycosides (1-3), including one new compound, namely stichorrenoside E (1) along with thelenotoside B (2) and deacetyl thelenotoside B (3), were isolated from the MeOH extract of the Vietnamese sea cucumber Stichopus horrens. Their structures were confirmed by spectroscopic experiments, such as 1D and 2D NMR and HR-ESI-MS. Deacetylated thelenotoside B (3) is firstly isolated as a natural product. Among these compounds, thelenotoside B (2) showed strong cytotoxicities against five human Cancer cell lines as HepG2, KB, LNCaP, MCF7 and SK-Mel2 with the IC50 values from 0.95 ± 0.08 to 1.90 ± 0.13 μM, whereas stichorrenoside E (1) and deacetyl thelenotoside B (3) exhibited significant activities with the IC50 values from 6.87 ± 0.25 to 11.62 ± 1.05 μM.

Keywords
Stichopodidae; Stichopus horrens; cytotoxicity; triterpene saponin.
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