Two new triterpenoids with antimicrobial activity from the leaves and twigs of Orophea yunnanensis

  • Nat Prod Res. 2019 Dec;33(24):3472-3477. doi: 10.1080/14786419.2018.1481843.
Wei Zhao  1 ,  Xiao-Wei Gong  1 ,  Yuan-Xing Duan  1 ,  Ji Yang  1 ,  Xia Wu  2 ,  Xian-Jun Jiang  3 ,  Xiao-Hua Xu  3 ,  Yong-Kuan Chen  1 ,  Liu Yang  1 ,  Fei Wang  3 ,  Xiao-Long Yang  2
Affiliations
  • 1. Research & Development Center, China Tobacco Yunnan Industrial Co., Ltd , Kunming , China.
  • 2. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University , Chongqing , P. R. China.
  • 3. BioBioPha Co., Ltd. , Kunming , China.
PMID: 29882434 DOI: 10.1080/14786419.2018.1481843
Abstract

Two new triterpenoids, 3-O-(4',5'-dihydroxybenzoyl)-lup-20(29)-en (1) and 3-O-(6'-desmethysyringyl)-13α-methyl-27-norolean-14-en-3β-ol (2), were isolated from the leaves and twigs of Orophea yunnanensis. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data. Compounds 1 and 2 exhibited the moderate inhibitory activity against Sclerotinia sclerotiorum, Ceratocystis fimbriata and Verticillium dahliae Kleb with MIC values from 50 to 25 μg/mL, and also displayed the weak activity selectively against tested bacteria strains with MIC values from 100 to 50 μg/mL.

Keywords
antibacterial activity; antifungal activity; triterpenoids.
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