Pharmacology and Therapeutic Potential of the 5-HT7 Receptor

  • ACS Chem Neurosci. 2019 Jan 16;10(1):89-119. doi: 10.1021/acschemneuro.8b00283.
Kevin M Blattner  1 ,  Daniel J Canney  1 ,  Douglas A Pippin  2 ,  Benjamin E Blass  1
Affiliations
  • 1. Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery Research , 3307 North Broad Street , Philadelphia , Pennsylvania 19140 , United States.
  • 2. Praeventix, LLC , 665 Stockton Drive, Suite 200H , Exton , Pennsylvania 19341 , United States.
PMID: 30020772 DOI: 10.1021/acschemneuro.8b00283
Abstract

It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first identified in 1993. Over the course of the last 25 years, this receptor has been the subject of intense investigation, and it has been demonstrated that 5-HT7 plays an important role in a wide range of pharmacological processes. As a result of these findings, modulation of 5-HT7 activity has been the focus of numerous drug discovery and development programs. This review provides an overview of the roles of 5-HT7 in normal physiology and the therapeutic potential of this interesting drug target.

Keywords
5-HT7 agonist; 5-HT7 antagonist; 5-HT7 receptor; G-protein-coupled receptor (GPCR); Serotonin receptor; serotonin (5-HT).