Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus

  • Nat Prod Res. 2020 May;34(10):1394-1398. doi: 10.1080/14786419.2018.1512990.
Thanika Promchai  1  2 ,  Pawinee Janhom  1 ,  Wisanu Maneerat  3 ,  Roonglawan Rattanajak  4 ,  Sumalee Kamchonwongpaisan  4 ,  Stephen G Pyne  5 ,  Thunwadee Limtharakul  1  6
Affiliations
  • 1. Department of Chemistry and Center of Excellence for Innovation in Chemistry Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
  • 2. The Graduate School, Chiang Mai University, Chiang Mai, Thailand.
  • 3. School of Science, Mae Fah Luang University, Chiang Rai, Thailand.
  • 4. Medical Molecular Biology Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, Thailand.
  • 5. School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia.
  • 6. Research Center on Chemistry for Development of Health Promoting Products from Northern Resources, Chiang Mai University, Chiang Mai, Thailand.
PMID: 30587032 DOI: 10.1080/14786419.2018.1512990
Abstract

A new 2-arylbenzofuran, spathobenzofuran (1), together with ten known compounds including a 2-arylbenzofuran, three pterocarpans and six Isoflavones were isolated from the acetone crude extract of the stems of Spatholobus parviflorus. All compounds were characterised by spectroscopic methods. Compound 4 was active (MIC 8 µg/mL) against Gram-negative Pseudomonas aeruginosa TISTR 781 while compound 2 had modest activity against Gram-positive Staphylococcus aureus TISTR 1466 with a MIC value of 16 µg/mL. All isolated compounds showed no cytotoxicity against Vero and KB cells.

Keywords
Spatholobus parviflorus; antibacterial activity; arylbenzofuran; cytotoxicity.
Products