Isolation, Characterization, and Possible Anti-Alzheimer's Disease Activities of Bisabolane-Type Sesquiterpenoid Derivatives and Phenolics from the Rhizomes of Curcuma longa

  • Chem Biodivers. 2020 May;17(5):e2000067. doi: 10.1002/cbdv.202000067.
Pei-Qian Wu  1 ,  Bing Li  1 ,  Yi-Fan Yu  1 ,  Pan-Jie Su  1 ,  Xu Liu  1 ,  Zong-Ping Zhang  1 ,  De-Juan Zhi  1 ,  Feng-Ming Qi  2 ,  Dong-Qing Fei  1 ,  Zhan-Xin Zhang  1
Affiliations
  • 1. School of Pharmacy, Lanzhou University, Lanzhou, 730000, P. R. China.
  • 2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China.
PMID: 32154990 DOI: 10.1002/cbdv.202000067
Abstract

One new bisabolane-type sesquiterpenoid, together with four known bisabolane-type sesquiterpenoid derivatives and seven phenolics, was isolated from the rhizomes of Curcuma longa. Their structures were elucidated by extensive spectroscopic (IR, HR-ESI-MS, and NMR) data analysis. The possible anti-Alzheimer's disease (AD) activities of the isolated compounds were also evaluated using Caenorhabditis elegans AD pathological model, and 1β-hydroxybisabola-2,10-dien-4-one had the highest possible anti-AD activity.

Keywords
Caenorhabditis elegans; Curcuma longa; bisabolane-type sesquiterpenoids; phenolics; possible anti-Alzheimer's disease activities.
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