Do antigen-presenting CD1a, CD1b, CD1c, and CD1d molecules bind different self-lipids?
- Trends Immunol. 2023 Oct;44(10):757-759. doi: 10.1016/j.it.2023.08.010.
Affiliations
- 1. Department of Medical Biology, Amsterdam University Medical Center, Amsterdam, The Netherlands; Department of Infectious Diseases and Immunology, School of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address: [email protected].
PMID: 37730500
DOI: 10.1016/j.it.2023.08.010
Abstract
Humans express four different lipid antigen-presenting molecules, CD1a, CD1b, CD1c, and CD1d, that are differentially expressed on antigen-presenting cells and which recycle through different endosomal compartments. Huang et al. now answer the question on whether the four CD1 isoforms selectively bind certain lipids.