Therapeutic Potential of Extracellular Vesicles Derived from Sheep Placenta in the Treatment of Skin Disorders

  • ACS Omega. 2026 Jun 18;11(25):37145-37158. doi: 10.1021/acsomega.6c01420.
Guiyang He  1  2  3  4 ,  Ruijie Fan  5 ,  Jie Zhao  4 ,  Juanjuan He  1 ,  Zhongtian Shi  1 ,  Peiyu Liu  5 ,  Heng Zhang  1 ,  Chong Wu  1 ,  Meng Jia  3  6  7 ,  Xudong Ao  7 ,  Junqing Liang  7 ,  Fang Lu  8 ,  Bing Liu  5 ,  Ke Zen  6 ,  Can Zhang  1 ,  Shaochang Jia  9 ,  Yongbin Liu  2  10 ,  Yaoxin Lu  5 ,  Jiangfeng He  2 ,  Hongwei Liang  1
Affiliations
  • 1. Department of Emergency, Nanjing Drum Tower Hospital, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
  • 2. Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot 010031, China.
  • 3. Sirius Technology (Nanjing) Co., Ltd, Nanjing 210033, China.
  • 4. The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
  • 5. Lushan Rehabilitation and Sanatorium Center, Jiujiang 332900, China.
  • 6. School of Life Science, Nanjing University, Nanjing 210023, China.
  • 7. Peking University Cancer Hospital (Inner Mongolia Campus), Hohhot 010020, China.
  • 8. Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 332000, China.
  • 9. Jiangsu Province Geriatric Hospital, Nanjing, Jiangsu 210000, China.
  • 10. Inner Mongolia Agricultural University, Hohhot 010050, China.
PMID: 42395991 DOI: 10.1021/acsomega.6c01420
Abstract

Skin disorders such as chronic wounds, inflammation, and premature aging remain difficult to treat due to limited therapies and poor regeneration. Extracellular vesicles (EVs) are emerging as promising cell-free therapeutics, but those from human placenta or stem cells face ethical, cost, and scalability barriers. Here, we isolated and characterized sheep placenta-derived EVs (spEVs), an ethical and sustainable alternative. SpEVs exhibited a bilayer structure (150 nm) and expressed typical exosomal markers. Their RNA and protein cargos were enriched in regenerative and anti-inflammatory pathways. Functionally, spEVs promoted keratinocyte proliferation, migration, and angiogenesis, and improved psoriasis-like, UVB-induced, and diabetic wounds in mice. This study identifies sheep placenta as a scalable and ethical source of EVs with promising preclinical potential for skin regeneration.

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