Vitamin K dependent carboxylation: study of diastereoisomeric gamma-methylglutamic acid containing peptidic substrates

  • Biochem Biophys Res Commun. 1983 Jun 15;113(2):454-61. doi: 10.1016/0006-291x(83)91747-3.
M Gaudry ,  S Bory ,  J Dubois ,  R Azerad ,  A Marquet
PMID: 6870869 DOI: 10.1016/0006-291x(83)91747-3
Abstract

Two pentapeptides Phe-Leu-X-Glu-Val where X is either the L-threo-gamma-methylglutamic acid or the L-erythro isomer have been synthesized and tested as substrates in the vitamin K dependent carboxylation. The gamma-methylglutamic residue is not carboxylated and both peptides are inhibitors of the carboxylation of the reference peptide Phe-Leu-Glu-Glu-Val. The threo containing isomer has a much better affinity than the reference and is the best inhibitor of this reaction described so far.

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