AS-183, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Scedosporium sp. SPC-15549

  • J Antibiot (Tokyo). 1993 Aug;46(8):1196-202. doi: 10.7164/antibiotics.46.1196.
K Kuroda  1 ,  M Yoshida ,  Y Uosaki ,  K Ando ,  I Kawamoto ,  E Oishi ,  H Onuma ,  K Yamada ,  Y Matsuda
Affiliations
  • 1. Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
PMID: 8407580 DOI: 10.7164/antibiotics.46.1196
Abstract

A novel compound, AS-183, which inhibits acyl-CoA: cholesterol Acyltransferase (ACAT), was isolated from the culture broth of a fungus, Scedosporium sp. SPC-15549. AS-183 inhibited ACAT activity in an enzyme assay system using rabbit liver microsomes with an IC50 value of 0.94 microM. AS-183 also inhibited Cholesterol ester formation in HepG2, CaCo2, and THP-1 cells with IC50 values of 18.1, 25.5, and 34.5 microM, respectively.

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