2. Protein Tyrosine Kinase/RTK
  3. Pyk2 FAK
  4. Pyk2-IN-2

Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM.

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Pyk2-IN-2

Pyk2-IN-2 構造式

CAS 番号 : 1271418-15-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 205 在庫あり
Solution
10 mM * 1 mL in DMSO USD 205 在庫あり
Solid
5 mg $200 在庫あり
10 mg $340 在庫あり
25 mg $714 在庫あり
50 mg $1214 在庫あり
100 mg $2065 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Pyk2-IN-2 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM[1].

IC50 & Target

IC50: 0.608 μM (FAK)[1]
Cellular Effect
Cell Line Type Value Description References
NIH3T3 IC50
98 nM
Compound: 13j
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay
Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assay
[PMID: 23153798]
体外実験

Pyk2-IN-2 (compound 13j) has an IC50 of 55 nM against PYK2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyk2-IN-2 関連抗体
体内実験

The HLM blood clearance of Pyk2-IN-2 (compound 13j) is 31 mL/min/kg[1].
Pharmacokinetic Analysis in male Wistar-Han rats[1]

Route Dose (mg/kg) t1/2 (h) Clp (mL/min/kg) Vdss (L/kg) Cmax (nM) Calc Cmax free (nM) %F PPB (fu)
i.v. 1 2.0 2.0 0.15 / / / 0.003
p.o. 30 / / / 61324 184 47 /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

465.55

分子式

C27H27N7O
CAS 番号
Appearance

Solid

Color

Off-white to gray

SMILES

O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=NNC(C4=CC5=C(N=CC=C5)C=C4)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (214.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1480 mL 10.7400 mL 21.4800 mL
5 mM 0.4296 mL 2.1480 mL 4.2960 mL
10 mM 0.2148 mL 1.0740 mL 2.1480 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.37 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 98.44%

COA (251 KB) HNMR (214 KB) RP-HPLC (262 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1480 mL 10.7400 mL 21.4800 mL 53.6999 mL
5 mM 0.4296 mL 2.1480 mL 4.2960 mL 10.7400 mL
10 mM 0.2148 mL 1.0740 mL 2.1480 mL 5.3700 mL
15 mM 0.1432 mL 0.7160 mL 1.4320 mL 3.5800 mL
20 mM 0.1074 mL 0.5370 mL 1.0740 mL 2.6850 mL
25 mM 0.0859 mL 0.4296 mL 0.8592 mL 2.1480 mL
30 mM 0.0716 mL 0.3580 mL 0.7160 mL 1.7900 mL
40 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3425 mL
50 mM 0.0430 mL 0.2148 mL 0.4296 mL 1.0740 mL
60 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8950 mL
80 mM 0.0268 mL 0.1342 mL 0.2685 mL 0.6712 mL
100 mM 0.0215 mL 0.1074 mL 0.2148 mL 0.5370 mL
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Pyk2-IN-2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyk2-IN-21271418-15-5Pyk2FAKProline-rich tyrosine kinase 2PTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasePyk2 inhibitorInhibitorinhibitorinhibit

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製品名:
Pyk2-IN-2
製品番号:
HY-401485
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