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Cat. No.: HY-116252

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(±)-trans-Lamivudine

(±)-trans-Lamivudine is separated from the salt of (S)-(+) mandelic acid. (±)-trans-Lamivudine forms cocrystals with (S)-BINOL. (±)-trans-Lamivudine is promising for research of human immunodeficiency virus infection.

For research use only. We do not sell to patients.

CAS No.: 131086-22-1
Formula: C₈H₁₁N₃O₃S
Molecular Weight:229.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

(±)-trans-Lamivudine Chemical Structure

CAS No.: 131086-22-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	EC₅₀	>100 μM Compound: 27 (-)-alpha	Concentration required for antiviral activity in PBMC (human peripheral blood mononuclear cells) infected with HIV-1 strain LAV Concentration required for antiviral activity in PBMC (human peripheral blood mononuclear cells) infected with HIV-1 strain LAV	[PMID: 8410975]
Vero	IC₅₀	>100 μM Compound: 27 (-)-alpha	Inhibition of cell growth in vero cells Inhibition of cell growth in vero cells	[PMID: 8410975]

Chemical Information

CAS No. 131086-22-1
Molecular Weight 229.26
Formula C₈H₁₁N₃O₃S
SMILES

O=C1N=C(C=CN1[C@@H]2CS[C@H](O2)CO)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Roy B N, et al. A novel method for large-scale synthesis of lamivudine through cocrystal formation of racemic lamivudine with (S)-(−)-1, 1’-Bi (2-naphthol)[(S)-(BINOL)][J]. Organic Process Research & Development, 2009, 13(3): 450-455.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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(±)-trans-Lamivudine

All HIV Isoforms