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BCAM Protein, Cynomolgus (HEK293, His)

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BCAM protein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein laminin. BCAM inhibits proliferation, migration, and invasion of trophoblast cells by inhibiting PIK3R6/p-STAT3 signaling, which may lead to placental dysplasia, resulting in a preeclampsia-like phenotype. BCAM also promotes ovarian cancer metastasis. BCAM Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BCAM protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Cynomolgus
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • BCAM Protein, Cynomolgus (HEK293, His) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

BCAM protein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein laminin. BCAM inhibits proliferation, migration, and invasion of trophoblast cells by inhibiting PIK3R6/p-STAT3 signaling, which may lead to placental dysplasia, resulting in a preeclampsia-like phenotype. BCAM also promotes ovarian cancer metastasis. BCAM Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BCAM protein, expressed by HEK293 , with C-His labeled tag.

Background

BCAM protein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein laminin. BCAM may play a role in red blood cell vessel occlusion in epithelial cell carcinoma and sickle cell disease. BCAM has been shown to interact with laminin α5. BCAM also promotes ovarian cancer metastasis. BCAM inhibits proliferation, migration, and invasion of trophoblast cells by inhibiting PIK3R6/p-STAT3 signaling, which may lead to placental-dysplasia, resulting in a preeclampsia-like a phenotype[1][2][3][4].

Technical Parameters

  • Species Cynomolgus
  • Source HEK293
  • Tag C-8*His
  • Accession

    A0A7N9CA99 (E32-G548)

  • Gene ID
    /
  • Molecular Construction
    • N-term
    • BCAM (E32-G548)
      Accession # A0A7N9CA99
    • 8*His
    • C-term
  • Protein Length

    Partial

  • Synonyms

    BCAM; F8/G253 Antigen; Prev. LU; Lutheran Blood Group (Auberger B Antigen Included); B-CAM Cell Surface Glycoprotein; Basal Cell Adhesion Molecule Lutheran Blood Group; Basal Cell Adhesion Molecule; Lutheran Blood Group Variant LUGA; F8/G253; Lutheran Blo

  • AA Sequence

    EVRLSVPPLVEVMRGKSVILNCTPTGAHDHYVLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGSLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGILSVMEDSAQEIATCNSRNGNPVPKITWYRNGQRLEVPVEMNPKGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPKGRHGRLDSPTFHLTLHYPTEHVQFWLGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNANFEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTHLGDGPMLSLSSITFDSNGTYICEASLPTVPVLSRTQNFTLLVQGLPELRAAEIEPKADGSWREGDEVTLICSTRGHPEPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAG

  • Predicted Molecular Mass

    57.4 kDa

  • Molecular Weight

    Approximately 70-80 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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