1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Erythrocyte CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. CD239/BCAM Immunoglobulin-like Cell Adhesion Molecules
  5. Basal Cell Adhesion Molecule (BCAM)
  6. BCAM Protein, Cynomolgus (HEK293, His)

BCAM Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P700662
SDS COA Handling Instructions

BCAM protein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein laminin. BCAM inhibits proliferation, migration, and invasion of trophoblast cells by inhibiting PIK3R6/p-STAT3 signaling, which may lead to placental dysplasia, resulting in a preeclampsia-like phenotype. BCAM also promotes ovarian cancer metastasis. BCAM Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BCAM protein, expressed by HEK293 , with C-His labeled tag. The total length of BCAM Protein, Cynomolgus (HEK293, His) is 517 a.a., with molecular weight of 70-80 kDa.

For research use only. We do not sell to patients.

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Size Price Stock Quantity
20 μg $145 In-stock
50 μg $280 In-stock
100 μg $450 In-stock
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  • Biological Activity

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Description

BCAM protein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein laminin. BCAM inhibits proliferation, migration, and invasion of trophoblast cells by inhibiting PIK3R6/p-STAT3 signaling, which may lead to placental dysplasia, resulting in a preeclampsia-like phenotype. BCAM also promotes ovarian cancer metastasis. BCAM Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BCAM protein, expressed by HEK293 , with C-His labeled tag. The total length of BCAM Protein, Cynomolgus (HEK293, His) is 517 a.a., with molecular weight of 70-80 kDa.

Background

BCAM protein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein laminin. BCAM may play a role in red blood cell vessel occlusion in epithelial cell carcinoma and sickle cell disease. BCAM has been shown to interact with laminin α5. BCAM also promotes ovarian cancer metastasis. BCAM inhibits proliferation, migration, and invasion of trophoblast cells by inhibiting PIK3R6/p-STAT3 signaling, which may lead to placental-dysplasia, resulting in a preeclampsia-like a phenotype[1][2][3][4].

Species

Cynomolgus

Source

HEK293

Tag

C-His

Accession

A0A7N9CA99 (E32-G548)

Gene ID

/

Molecular Construction
N-term
BCAM (E32-G548)
Accession # A0A7N9CA99
His
C-term
Synonyms
LU; MSK19; Gplu; CD239; Lutheran;
Molecular Weight

70-80 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
BCAM Protein, Cynomolgus (HEK293, His)
Cat. No.:
HY-P700662
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