BCAM Protein, Cynomolgus (HEK293, His)

BCAM protein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein laminin. BCAM inhibits proliferation, migration, and invasion of trophoblast cells by inhibiting PIK3R6/p-STAT3 signaling, which may lead to placental dysplasia, resulting in a preeclampsia-like phenotype. BCAM also promotes ovarian cancer metastasis. BCAM Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived BCAM protein, expressed by HEK293 , with C-His labeled tag.

BCAM protein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein laminin. BCAM may play a role in red blood cell vessel occlusion in epithelial cell carcinoma and sickle cell disease. BCAM has been shown to interact with laminin α5. BCAM also promotes ovarian cancer metastasis. BCAM inhibits proliferation, migration, and invasion of trophoblast cells by inhibiting PIK3R6/p-STAT3 signaling, which may lead to placental-dysplasia, resulting in a preeclampsia-like a phenotype^[1][2][3][4].

Cynomolgus

HEK293

C-8*His

A0A7N9CA99 (E32-G548)

/

Partial

EVRLSVPPLVEVMRGKSVILNCTPTGAHDHYVLEWFLTDRSGARPRLASAEMQGSELQVTMHDTRGRSPPYQLDSQGSLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGILSVMEDSAQEIATCNSRNGNPVPKITWYRNGQRLEVPVEMNPKGYMTSRTVREASGLLSLTSTLYLRLRKDDRDASFHCAAHYSLPKGRHGRLDSPTFHLTLHYPTEHVQFWLGSPSTPAGWVREGDTVQLLCRGDGSPSPEYTLFRLQDEQEEVLNANFEGNLTLEGVTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPLELSEGKVLSLPLNSSAVVNCSVHGLPTPALRWTKDSTHLGDGPMLSLSSITFDSNGTYICEASLPTVPVLSRTQNFTLLVQGLPELRAAEIEPKADGSWREGDEVTLICSTRGHPEPKLSWSQLGGSPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAG

70-80 kDa

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.