MT-RNR1 Protein, Human (His, GST)
Based on 1 Customer Validation
MT-RNR1 Protein, Human (His, GST) is the recombinant human-derived MT-RNR1, expressed by E. coli , with His, GST labeled tag. ,
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
MT-RNR1 Protein, Human (His, GST) is the recombinant human-derived MT-RNR1, expressed by E. coli , with His, GST labeled tag. ,
Background
MT-RNR1 regulates insulin sensitivity and metabolic homeostasis by inhibiting the folate cycle, reducing de novo purine biosynthesis, and accumulating the intermediate AICAR to activate AMPK. It protects against age-related and diet-induced insulin resistance and obesity. Under metabolic stress, it translocates to the nucleus, binds to AREs, and modulates gene expression in an NFE2L2-dependent manner to enhance cellular stress resistance. Additionally, it increases mitochondrial respiration and levels of CPT1A and cytokines (IL1B, IL6, IL8, IL10, TNF) in senescent cells. MT-RNR1 enhances mTORC2 activity while suppressing PTEN, promoting AKT phosphorylation and subsequent FOXO1 inhibition, reducing MSTN levels to stimulate skeletal muscle growth. Via the TGFB/SMAD pathway, it drives osteogenic differentiation of bone marrow mesenchymal stem cells and boosts osteoblast proliferation and type I collagen (COL1A1, COL1A2) synthesis.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-His;N-GST
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Accession
A0A0C5B5G6 (R2-R16)
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Gene ID/
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Protein Length
Full Length
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Synonyms
Mitochondrial-derived peptide MOTS-c; Mitochondrial open reading frame of the 12S rRNA-c; MT-RNR1
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AA Sequence
RWQEMGYIFYPRKLR
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Predicted Molecular Mass
29.5 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Supplied as a 0.22 μm filtered solution of 50 mM HEPES , pH 7.5, 200 mM NaCl, 20% glycerol, 1 mM DTT.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (234 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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