Rezivertinib hydrochloride
Based on 1 publication(s) in Google Scholar
Rezivertinib (BPI-7711) hydrochloride is an orally active, highly selective and irreversible third-generation EGFR tyrosine kinase inhibitor (TKI). Rezivertinib hydrochloride exhibits high potency against the common activation EGFR and the resistance T790M mutations. Rezivertinib hydrochloride has excellent central nervous system (CNS) penetration and has antitumor activity, such as non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- CAS No.: 2170255-78-2
- Formula: C27H31ClN6O3
- Molecular Weight:523.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Rezivertinib hydrochloride
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Biological Activity
Rezivertinib (BPI-7711) hydrochloride selectively inhibits cellular proliferation of EGFR mutations in cell lines: GI50 13.3 nM (PC9, del19), 6.8 nM (HCC827, L858R), 22 nM (NCI-H1975, del19/T790M) and > 1000 nM (A431, EGFR WT)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Rezivertinib (12.5 mg/kg/day; orally; 14 days) hydrochloride survives an average of 112% longer in H1975-luc human NSCLC mice model[2].
Rezivertinib (50 mg/kg/day; orally) hydrochloride has anti-tumor efficacy correlated to improved average overall survival of the animals of 115% (28 days vs. 13 days)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2170255-78-2
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Molecular Weight 523.03
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Formula C27H31ClN6O3
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SMILES
O=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1OCCN(C)C)OC)C=C.Cl
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Synonyms
BPI-7711 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rezivertinib hydrochloride Related Classifications
HY-109189A Related Classifications
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