2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. (S)-LTGO-33

(S)-LTGO-33 is a small molecule inhibitor of voltage-gated sodium channel NaV1.8. (S)-LTGO-33 can be used in the study of pain disorders.

Para uso exclusivo en investigación. No vendemos a pacientes.

(S)-LTGO-33

(S)-LTGO-33 Estructura química

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

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Other Forms of (S)-LTGO-33:

(S)-LTGO-33 Related Antibodies

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Descripciòn

(S)-LTGO-33 is a small molecule inhibitor of voltage-gated sodium channel NaV1.8. (S)-LTGO-33 can be used in the study of pain disorders[1].

Peso molecular

467.44

Fòrmula

C21H17F4N3O3S
Appearance

Solid

Color

Off-white to light yellow

SMILES

FC1=CC(C)=C(OC2=NC=C(C=C2C(NC3=CC=CC([S@@](=O)(C)=N)=C3)=O)C(F)(F)F)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 200 mg/mL (427.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1393 mL 10.6966 mL 21.3931 mL
5 mM 0.4279 mL 2.1393 mL 4.2786 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1393 mL 10.6966 mL 21.3931 mL 53.4828 mL
5 mM 0.4279 mL 2.1393 mL 4.2786 mL 10.6966 mL
10 mM 0.2139 mL 1.0697 mL 2.1393 mL 5.3483 mL
15 mM 0.1426 mL 0.7131 mL 1.4262 mL 3.5655 mL
20 mM 0.1070 mL 0.5348 mL 1.0697 mL 2.6741 mL
25 mM 0.0856 mL 0.4279 mL 0.8557 mL 2.1393 mL
30 mM 0.0713 mL 0.3566 mL 0.7131 mL 1.7828 mL
40 mM 0.0535 mL 0.2674 mL 0.5348 mL 1.3371 mL
50 mM 0.0428 mL 0.2139 mL 0.4279 mL 1.0697 mL
60 mM 0.0357 mL 0.1783 mL 0.3566 mL 0.8914 mL
80 mM 0.0267 mL 0.1337 mL 0.2674 mL 0.6685 mL
100 mM 0.0214 mL 0.1070 mL 0.2139 mL 0.5348 mL
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(S)-LTGO-33 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-LTGO-33Sodium ChannelNa channelsNa+ channelspain disordersVSDIIcynomolgus monkeyDRG neuronsInhibitorinhibitorinhibit

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Nombre del producto:
(S)-LTGO-33
Cat. No.:
HY-157802A
Cantidad:
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