1. Antibody-drug Conjugate/ADC Related
    Anti-infection
  2. ADC Cytotoxin
    Bacterial
    Antibiotic
  3. Sandramycin

Sandramycin 

Cat. No.: HY-19829
Handling Instructions

Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.

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Sandramycin Chemical Structure

Sandramycin Chemical Structure

CAS No. : 100940-65-6

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Description

Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity[1][2][3].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

In Vitro

Sandramycin has antimicrobial activity wtih MIC values of 0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Bacillus subtilis (Rec+) A22508-2, B. subtilis (Rec-) A22509-2-2, Staphylocccus aureus 209P-A9497, S. aureus (echinomycin-resistant) A9628, Streptococcus faecalis A96 1 1, Escherichia coli A151 19 and E. coli (actinomycin-sensitive) A21780 (AS-19), respectively[1].
Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC50 values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively[2].

In Vivo

Sandramycin (0.0125-1.6 mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice[1].

Animal Model: CDF1 female mice injected with leukemia P388 cells[1]
Dosage: 0.0125 mg/kg, 0.025 mg/kg, 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg, 0.4 mg/kg, 0.8 mg/kg, 1.6 mg/kg
Administration: Intraperitoneal injection; daily; for 5 days
Result: Was moderately active in vivo against leukemia P388 in mice.
Molecular Weight

1221.32

Formula

C₆₀H₇₆N₁₂O₁₆

CAS No.

100940-65-6

SMILES

CC(C)[[email protected]@H](C(OC[[email protected]@H](NC(C1=C(O)C=C(C=CC=C2)C2=N1)=O)C3=O)=O)N(C)C(CN(C)C(CNC([[email protected]@H]4CCCCN4C([[email protected]@H](COC([[email protected]](C(C)C)N(C)C(CN(C)C(CNC([[email protected]]5N3CCCC5)=O)=O)=O)=O)NC(C6=C(O)C=C(C=CC=C7)C7=N6)=O)=O)=O)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SandramycinADC CytotoxinBacterialAntibioticDNAintercalatordepsipeptideantibioticantitumorGram-positivebis-intercalationCytotoxinADCInhibitorinhibitorinhibit

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