Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. Production, isolation, characterization and biological properties

  • J Antibiot (Tokyo). 1989 Dec;42(12):1763-7. doi: 10.7164/antibiotics.42.1763.
J A Matson  1 ,  J A Bush
Affiliations
  • 1. Pharmaceutical Research and Development Division, Bristol-Myers Company, Wallingford, Connecticut 06492.
PMID: 2621159 DOI: 10.7164/antibiotics.42.1763
Abstract

A new antitumor Antibiotic, sandramycin, was isolated from cultured broth of a Nocardioides sp. (ATCC 39419) and purified by solvent partition and column chromatography. Sandramycin, a new depsipeptide, was moderately active in vitro against Gram-positive organisms and in vivo against leukemia P388 in mice.

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