Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
colonization
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "colonization" in MCE Product Catalog:
Cat. No.: HY-184277
Research Areas:
Tubulin/PARP1-IN-1 is a dual inhibitor of tubulin and PARP1, with IC50 values of 1.86 μM and 0.88 μM, respectively. Tubulin/PARP1-IN-1 arrests cancer cells at the G2/M phase, induces cancer cell apoptosis, enhances cellular DNA damage, inhibits tumor angiogenesis, reduces cancer cell colonization and dissemination, and exhibits antiproliferative activity against colorectal cancer cells. Tubulin/PARP1-IN-1 can be used in the research of colorectal cancer and colorectal cancer lung metastasis .
Cat. No.: HY-182639
CAS No.: 1869033-49-7
Target:
Research Areas:
AM9928 is a monoacylglycerol lipase (MAGL) inhibitor with IC50 and Ki values of 8.9 nM and 7.3 nM, respectively. AM9928 blocks the adhesion and migration of triple-negative breast cancer (TNBC) cells, and inhibits the secretion of IL-6, IL-8 and VEGF-A by TNBC cells. AM9928 suppresses the activation of human brain microvascular endothelial cells (HBMECs) induced by TNBC-derived exosomes, and reduces the secretion of IL-8 and VEGF-A by HBMECs. AM9928 attenuates changes in blood-brain barrier permeability, inhibits tumor growth in the mammary fat pad, and reduces brain colonization of TNBC. AM9928 can be used in studies related to triple-negative breast cancer .
Cat. No.: HY-15651B
CAS No.: 1240425-11-9
Synonyms: AZD9668 hydrochloride
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Alvelestat hydrochloride (AZD9668 hydrochloride) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat hydrochloride reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat hydrochloride restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat hydrochloride prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat hydrochloride inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat hydrochloride can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
Cat. No.: HY-E70115A
Feruloyl esterase, Acetivibrio cellulolyticus is a subclass of carboxylesterases that hydrolyzes the ester linkages between hydroxycinnamic acids and arabinoxylan/pectin polysaccharides in plant cell walls. Feruloyl esterase, Acetivibrio cellulolyticus can hydrolyze ethyl ferulate to release ferulic acid, disrupt plant cell wall structure, promote fiber swelling, and facilitate cellulase hydrolysis. Feruloyl esterase, Acetivibrio cellulolyticus synergizes with xylanase by removing ferulic acid side chains, thereby promoting efficient hydrolysis of xylan into monomers. Feruloyl esterase, Acetivibrio cellulolyticus acts as a virulence factor for Verticillium dahliae VdFAE and Magnaporthe oryzae Fae1, facilitating host infection and colonization. Feruloyl esterase, Acetivibrio cellulolyticus promotes the degradation of cotton GhDFR through binding to its NADPH domain, thereby inhibiting flavonoid-mediated innate immunity and inducing cell death in Nicotiana benthamiana. Feruloyl esterase, Acetivibrio cellulolyticus can be used in studies related to verticillium wilt and rice blast .
Cat. No.: HY-N16818
CAS No.: 1242672-31-6
Category:
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
