Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
205 Results for "
OPTimization
" in MedChemExpress (MCE) Product Catalog:
Products (205)
205 Results for "OPTimization" in MCE Product Catalog:
Cat. No.: HY-128230
CAS No.: 485362-61-6
Synonyms: MLS-0073383
Target:
Research Areas:
WAY-605337 (MLS-0073383) is a Bcl-B inhibitor, which can be used for structural modification and optimization of scaffolds .
Cat. No.: HY-K3121
MCE Bacterial Membrane Vesicle Isolation and Purification Kit has been optimized specifically for the isolation and purification of bacterial membrane vesicles. The optimized formulation and purification workflow enable the isolation and purification of bacterial membrane vesicles from bacterial culture supernatants. In combination with an exosome purification column, the kit enables rapid and efficient enrichment of bacterial membrane vesicles, yielding vesicle particles with high purity and preserved structural integrity.
Cat. No.: HY-L942
1,626 compounds
Unlike highly conserved orthosteric sites, allosteric sites exhibit low conservation, high hydrophobicity, weak polarity, confined geometry, and dynamic cryptic properties. Rather than rigid keyhole-like cavities, they typically appear as flexible grooves, subunit interface clefts, or shallow depressions formed by protein conformational changes.
Based on the dynamic, hydrophobic, and elongated nature of allosteric pockets, MCE has carried out targeted fragment modification and screening under strict physicochemical criteria: MW 120–280 Da, HBD ≤ 2, HBA ≤ 3, PSA 30–80 Ų, rotatable bonds ≤ 2, cLogP 1–3.5. High 3D diversity was further ensured by PMI analysis, yielding fragments with excellent shape complementarity to allosteric pockets.
This library contains 1,800 structurally diverse, drug-like fragments, this library supports allosteric drug development and pocket optimization. It significantly improves screening hit rates and enables efficient, precise early-stage R&D of allosteric drugs.
Cat. No.: HY-K3122
MCE Dry Plant-Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for dried plant samples. It facilitates the efficient release of vesicles from plant tissues and employs an optimized extraction and purification system to remove non-vesicular components such as polysaccharides and phenolic compounds, thereby enabling the efficient extraction and purification of plant-derived vesicles. The isolated plant-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.
Cat. No.: HY-K3123
MCE Succulent Plant -Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for succulent plant samples. It facilitates the efficient release of vesicles from plant tissues and employs an optimized extraction and purification system to remove non-vesicular components such as polysaccharides and phenolic compounds, thereby enabling the efficient extraction and purification of plant-derived vesicles. The isolated plant-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.
Cat. No.: HY-K3124
MCE Macrofungal-Derived Extracellular Vesicle Isolation and Purification Kit is specifically optimized for fungal fruiting body samples. The optimized extraction system facilitates the release of EVs from fungal tissues, while the purification system effectively removes polysaccharides, proteins, phenolic compounds, terpenoids, and other non-vesicular components, enabling efficient isolation and purification of fungal EVs. The isolated macrofungal-derived vesicles can be used for downstream applications including transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting, qPCR, cell-based studies, and animal experiments.
Cat. No.: HY-185838
Target:
Research Areas:
FAM-labeled Human beta-actin siRNA is a human β-actin (ACTB) gene siRNA with a FAM fluorescent label, primarily used for transfection efficiency assessment, siRNA delivery optimization, and fluorescence tracking.
Cat. No.: HY-180281
CAS No.: 3099026-16-8
Target:
Research Areas:
PLAGL2-IN-1 is a inhibitor of pleiomorphic adenoma-like protein 2 (PLAGL2) with a Kd of 2.23 µM. PLAGL2-IN-1 suppresses PLAGL2 transcriptional activity, induces G0/G1 cell cycle arrest, and apoptosis, thereby inhibiting hepatocellular carcinoma (HCC) cell proliferation. PLAGL2-IN-1 disrupts extracellular matrix organization and suppresses the PI3K-AKT pathway by reducing AKT phosphorylation. PLAGL2-IN-1 inhibits tumor growth in an HCCLM3 xenograft mouse model. PLAGL2-IN-1 can be used for the research of HCC .
Cat. No.: HY-K0315A
MCE Hematoxylin-Eosin Staining Kit (Including Differentiation and Bluing Solutions) contains staining solutions, differentiation solution, and bluing solution. Through optimized formulations, it helps to adjust the staining effect, ensuring proper staining intensity and further improving experimental accuracy.
Cat. No.: HY-182449
CAS No.: 2647503-59-9
Target:
Research Areas:
CCT365386 is a BCL6 inhibitor. CCT365386 serves as an optimized lead compound for cell-active BCL6 degraders (including CCT369260 (HY-129188)). CCT365386 can be used in the research of B-cell lymphoma .
Cat. No.: HY-185838A
Target:
Research Areas:
Cy3-labeled Human beta-actin siRNA is a human β-actin (ACTB) gene siRNA with a Cy3 fluorescent label, primarily used for transfection efficiency assessment, siRNA delivery optimization, and fluorescence tracking.
Cat. No.: HY-N14661
CAS No.: 71203-17-3
Category:
Target:
Cat. No.: HY-W127512R
CAS No.: 546-18-9
Target:
Research Areas:
5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems .
Cat. No.: HY-K6101A
MCE Human Breast Cancer Organoid Complete Culture Medium is a pre-mixed, ready-to-use formulation composed of a basal breast cancer organoid medium and multiple key culture supplements at optimized ratios. This medium requires no additional preparation and enables the efficient and stable establishment of human breast cancer organoid models.
Cat. No.: HY-K6104A
MCE Human Colorectal Cancer Organoid Complete Culture Medium is a pre-mixed, ready-to-use formulation composed of a basal colorectal cancer organoid medium and multiple key culture supplements at optimized ratios. This medium requires no additional preparation and enables the efficient and stable establishment of human colorectal cancer organoid models.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
