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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
93 Results for "
H pump
" in MedChemExpress (MCE) Product Catalog:
Products (93)
93 Results for "H pump" in MCE Product Catalog:
Cat. No.: HY-P810986
Synonyms: CGI-11, ATP6V1H, V-type proton ATPase subunit H, V-ATPase subunit H, Nef-binding protein 1, Protein VMA13 homolog, V-ATPase 50/57 kDa subunits, Vacuolar proton pump subunit H, Vacuolar proton pump subunit SFD, NBP1
Cat. No.: HY-19153A
CAS No.: 157564-11-9
Synonyms: rel-TY-11345
Target:
Research Areas:
Nepaprazole sodium (rel-TY-11345) is a proton pump H+/K+-ATPase inhibitor. Nepaprazole sodium inhibits H+/K+-ATPase activity in rabbit gastric mucosal microsomes, with IC50 values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively, and its inhibitory activity is enhanced under weakly acidic conditions. Nepaprazole sodium inhibits basal and Tetragastrin (HY-125556)-stimulated gastric acid secretion. Nepaprazole sodium can be used in studies on gastric proton pump function, gastric acid secretion, and mechanisms related to peptic ulcers .
Cat. No.: HY-109079AR
CAS No.: 1902954-87-3
Synonyms: DWP14012 hydrochloride (Standard); Fexuprazan hydrochloride (Standard)
Target:
Research Areas:
Abeprazan hydrochloride (Standard) is the analytical standard of Abeprazan (hydrochloride) (HY-109079A). This product is intended for research and analytical applications. Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases .
Cat. No.: HY-109079R
CAS No.: 1902954-60-2
Synonyms: DWP14012 (Standard); Fexuprazan (Standard)
Target:
Research Areas:
Abeprazan (Standard) is the analytical standard of Abeprazan (HY-109079). This product is intended for research and analytical applications. Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases .
Cat. No.: HY-109079AS
Synonyms: DWP14012-d3 hydrochloride; Fexuprazan-d3 hydrochloride
Target:
Research Areas:
Abeprazan-d3 (DWP14012-d3) hydrochloride is the deuterated-labeled Abeprazan hydrochloride (HY-109079A). Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H +, K +- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.
Cat. No.: HY-P812033
Synonyms: ATP6V1E1; ATPase H+ Transporting V1 Subunit E1; ATP6E2; P31; ATP6E; Vma4; ATPase, H+ Transporting, Lysosomal 31kDa, V1 Subunit E1; V-Type Proton ATPase Subunit E 1; Vacuolar Proton pump Subunit E 1; V-ATPase 31 KDa Subunit; V-ATPase Subunit E 1; ATP6V1E; ATPase, H+ Transporting, Lysosomal 31kDa, V1 Subunit E Isoform 1; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton pump) 31kD; H(+)-Transporting Two-Sector ATPase, 31kDa Subunit; H+-Transporting ATP Synthase Chain E, Vacuolar; V-ATPase Subunit E1; V-ATPase, Subunit E; ARCL2C
Cat. No.: HY-P812033A
Synonyms: ATP6V1E1; ATPase H+ Transporting V1 Subunit E1; ATP6E2; P31; ATP6E; Vma4; ATPase, H+ Transporting, Lysosomal 31kDa, V1 Subunit E1; V-Type Proton ATPase Subunit E 1; Vacuolar Proton pump Subunit E 1; V-ATPase 31 KDa Subunit; V-ATPase Subunit E 1; ATP6V1E; ATPase, H+ Transporting, Lysosomal 31kDa, V1 Subunit E Isoform 1; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton pump) 31kD; H(+)-Transporting Two-Sector ATPase, 31kDa Subunit; H+-Transporting ATP Synthase Chain E, Vacuolar; V-ATPase Subunit E1; V-ATPase, Subunit E; ARCL2C
Cat. No.: HY-P72099
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP6AP2; ER-Localized Type I Transmembrane Adapter; Prev. ATP6IP2; Prorenin Receptor; Renin Receptor; ELDF10; ATP6M8-9; N14F; ATPase H(+)-Transporting Lysosomal-Interacting Protein 2; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton pump) Membrane Sect
Species:
Human
Source:
E. coli
Cat. No.: HY-P72100
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP6AP2; ER-Localized Type I Transmembrane Adapter; Prev. ATP6IP2; Prorenin Receptor; Renin Receptor; ELDF10; ATP6M8-9; N14F; ATPase H(+)-Transporting Lysosomal-Interacting Protein 2; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton pump) Membrane Sect
Species:
Human
Source:
E. coli
Cat. No.: HY-P76159A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ATP6V1F; Vacuolar Proton pump Subunit F; ATPase H+ Transporting V1 Subunit F; V-ATPase 14 KDa Subunit; ATP6S14; H(+)-Transporting Two-Sector ATPase, 14kD Subunit; VATF; Adenosinetriphosphatase 14k Chain; V-Type Proton ATPase Subunit F; Vacuolar ATP Syntha
Species:
Human
Source:
E. coli
Cat. No.: HY-P76159
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ATP6V1F; Vacuolar Proton pump Subunit F; ATPase H+ Transporting V1 Subunit F; V-ATPase 14 KDa Subunit; ATP6S14; H(+)-Transporting Two-Sector ATPase, 14kD Subunit; VATF; Adenosinetriphosphatase 14k Chain; V-Type Proton ATPase Subunit F; Vacuolar ATP Syntha
Species:
Human
Source:
E. coli
Cat. No.: HY-187719
CAS No.: 318262-42-9
Target:
Research Areas:
NIK-12192 is an orally active inhibitor of vacuolar H +-ATPase. NIK-12192 reduces intracellular pH, decreases lysosomal volume and acidity, and alters the intracellular localization of V-ATPase by inhibiting proton pumps . NIK-12192 induces αvβ5 integrin polarization, cytoskeletal disruption, cell detachment, anoikis-mediated delayed apoptosis and necrosis, a delayed reduction in mitochondrial membrane potential, and lysosomal/phagosomal accumulation. NIK-12192 inhibits tumor cell migration, invasion, and three-dimensional spheroid growth, and enhances the activity of Topotecan (HY-13768). NIK-12192 suppresses spontaneous lung metastasis in vivo. NIK-12192 is used in research related to colon cancer, ovarian cancer, lung cancer, breast cancer, renal cancer, prostate cancer, acute myeloid leukemia, and melanoma .
Cat. No.: HY-N20708
CAS No.: 89353-99-1
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
