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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
875 Results for "
α2
" in MedChemExpress (MCE) Product Catalog:
Products (875)
875 Results for "α2" in MCE Product Catalog:
130
130 Publications Verification
Synonyms: STA-4783
Research Areas:
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research [2] .
74
74 Cited Publications
Synonyms: Levarterenol; L-Noradrenaline
74
74 Cited Publications
Synonyms: Levarterenol hydrochloride; L-Noradrenaline hydrochloride
74
74 Cited Publications
Synonyms: Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate
74
74 Cited Publications
Synonyms: Levarterenol tartrate; L-Noradrenaline tartrate
55
55 Cited Publications
Target:
Research Areas:
PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM [2].
32
32 Cited Publications
Synonyms: (+)-Medetomidine; (S)-Medetomidine
Target:
Research Areas:
Dexmedetomidine ((+)-Medetomidine) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine exhibits anxiolysis, sedation, and modest analgesia effects [2] .
32
32 Cited Publications
Cat. No.: HY-17034A
CAS No.: 145108-58-3
Synonyms: (+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride
Target:
Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects [2] .
20
RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity . RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α . RRx-001 is a potent inhibitor of G6PD and shows potent antimalarial activity .
18
Target:
15
15 Cited Publications
Synonyms: PT2977; MK-6482
Target:
Research Areas:
Belzutifan (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is a potential treatment for clear cell renal cell carcinoma (ccRCC) .
12
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect [2] .
12
12 Cited Publications
Cat. No.: HY-B0219A
CAS No.: 17795-21-0
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect [2] .
11
Category:
Target:
11
11 Cited Publications
Target:
Research Areas:
PT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo [2] .
10
10 Cited Publications
Cat. No.: HY-P7022
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNA2; IFN-Alpha-2; Interferon Alpha 2; IFNA2B; IFN-AlphaA; LeIF A; IFNA; Interferon Alpha 2a; Alpha-2a Interferon; Interferon Alpha-A; Interferon Alpha 2b; Interferon 1AB4; Interferon Alpha A; IFNA2C; Interferon Alpha-2; IFNA2A
9
Target:
Research Areas:
Atipamezole (MPV 1248) is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM .
9
9 Cited Publications
Synonyms: MPV-1248 hydrochloride
Target:
Research Areas:
Atipamezole (MPV-1248) hydrochloride is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM .
9
9 Cited Publications
Synonyms: (S)-2-Amino-3-phenylpropionic acid
9
9 Cited Publications
Cat. No.: HY-P7365
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NRG1; NRG1 Class VII Isoform Alpha 2a; Prev. HGL; NRG1 Class VII Isoform Beta 2a; Prev. NRG1-IT2; Neuregulin 1 Isoform HRG-Gamma; NDF; Neuregulin 1 Isoform HRG-Beta3; GGF; Neuregulin 1 Isoform HRG-Beta2; Pro-Neuregulin-1, Membrane-Bound Isoform; Neureguli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
