1672665-49-4
1672665-49-4
Chemical Structure
PT-2385
- CAS No.: 1672665-49-4
- Formula:C17H12F3NO4S
- Molecular Weight:383.34
IUPAC Name: (S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile
InChIKey: ONBSHRSJOPSEGS-INIZCTEOSA-N
SMILES: N#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C)=O)C3=C2CC(F)(F)[C@H]3O)=C1
Biological Activity: PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PT-2385 | 99.95% | PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.86
HY-108697PT2399 -
Similarity Score 0.86
HY-108697AR(Rac)-PT2399 (Standard) -
Similarity Score 0.83
HY-130264HIF-2α-IN-2 -
Similarity Score 0.75
HY-125840RBelzutifan (Standard) -
Similarity Score 0.62
HY-19949HIF-2α-IN-1 -
Similarity Score 0.56
HY-148264Imdatifan -
Similarity Score 0.51
HY-144178HIF-2α-IN-6 -
Similarity Score 0.47
HY-163598HIF-2α-IN-11 -
Similarity Score 0.44
HY-149886HIF-2α-IN-9 -
Explore the MedChemAI to find more analogs
References
- [1]. Eli Wallace, Ph.D. PT2385: HIF-2α Antagonist for the Treatment of VHL Mutant ccRCC. 12th International VHL Medical Symposium April 8, 2016.
- [2]. Xie C, et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017 Nov;23(11):1298-1308. [Content Brief]
