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Cat. No.: HY-149886

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HIF-2α-IN-9

HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC₅₀=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2648334-36-3
화학식: C₁₂H₁₃F₅O₄S₂
분자량:380.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

HIF-2α-IN-9 Chemical Structure

CAS No.: 2648334-36-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

HIF-2α^[1]

All HIF/HIF Prolyl-Hydroxylase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	IC₅₀	80 nM Compound: 35r	Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis	[PMID: 37403966]

Chemical Information

CAS No. 2648334-36-3
분자량 380.35
화학식 C₁₂H₁₃F₅O₄S₂
SMILES

FC1(F)[C@@H](O)C2=C(S(=O)(C)=O)SC(OC[C@H](C)C(F)(F)F)=C2C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Buchstaller H P, et al. Discovery of Cycloalkyl [c] thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2伪 Inhibitors[J]. Journal of Medicinal Chemistry, 2023..

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

HIF-2α-IN-9

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HIF-2α-IN-9 Related Classifications

HY-149886 Related Classifications

Bioz

Keywords

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