HIF-2α-IN-9
HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity.
For research use only. We do not sell to patients.
- CAS No.: 2648334-36-3
- Formula: C12H13F5O4S2
- Molecular Weight:380.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HIF-2α[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | IC50 |
80 nM
Compound: 35r
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Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis
Antitumor activity against mouse J774.A1 cells assessed as downregulation of IL-4 stimulated Arg1 mRNA expression incubated for 48 hrs by qRT-PCR analysis
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[PMID: 37403966] |
Chemical Information
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CAS No. 2648334-36-3
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Molecular Weight 380.35
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Formula C12H13F5O4S2
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SMILES
FC1(F)[C@@H](O)C2=C(S(=O)(C)=O)SC(OC[C@H](C)C(F)(F)F)=C2C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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