925206-65-1
Chemical Structure
RRx-001
Synonym(s): Nibrozetone
- CAS No.: 925206-65-1
- Formula:C5H6BrN3O5
- Molecular Weight:268.02
IUPAC Name: 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one
InChIKey: JODKFOVZURLVTG-UHFFFAOYSA-N
SMILES: BrCC(N1CC([N+]([O-])=O)([N+]([O-])=O)C1)=O
Biological Activity: RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity[1]. RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α[2]. RRx-001 is a potent inhibitor of G6PD and shows potent antimalarial activity[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RRx-001 | 99.79% | RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity. RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α. RRx-001 is a potent inhibitor of G6PD and shows potent antimalarial activity. | ||||||||||||||||||||
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References
- [1]. Das DS, et al. A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells. Leukemia. 2016 Nov;30(11):2187-2197. [Content Brief]
- [2]. Yalcin O, et al. From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria. Malar J. 2015 May 28;14:218. [Content Brief]
- [3]. Cabrales P, et al. RRx-001 Acts as a Dual Small Molecule Checkpoint Inhibitor by Downregulating CD47 on Cancer Cells and SIRP-α on Monocytes/Macrophages. Transl Oncol. 2019 Apr;12(4):626-632. [Content Brief]
