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Results for "

α9α10

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

3

Peptides

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12152
    PNU-120596
    1 Publications Verification

    NSC 216666

    		 nAChR Neurological Disease Inflammation/Immunology
    PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) that can cross the blood-brain barrier, with an EC50 of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research .
    PNU-120596
  • HY-P10898
    GeX-2

    		nAChR Calcium Channel GABA Receptor Neurological Disease
    GeX-2 is a truncated analogue of αO-conotoxin. GeX-2 activates GABAB receptor. GeX-2 inhibits α9α10 nAChR and CaV2.2 channels. GeX-2 alleviates pain in the rat model of chronic constriction injury .
    GeX-2
  • HY-138973A
    Neramexane mesylate

    		iGluR nAChR Neurological Disease
    Neramexane mesylate is an α9α10 cholinergic nicotinic receptors and N-methyl-D-aspartate receptors(NMDA) antagonist. Neramexane mesylate can improve moderate to severe tinnitus, and also shows neuroprotective effects .
    Neramexane mesylate
  • HY-P11249
    Mr1.1[S4Dap, C16Pen]

    		nAChR Neurological Disease
    Mr1.1[S4Dap, C16Pen] is a highly active and selective nAChR (human α9α10 nAChR IC50 = 4.0 nM, rat α9α10 nAChR IC50 = 2.7 nM) inhibitor. Mr1.1[S4Dap, C16Pen] can significantly relieve pain and has significant stability. Mr1.1[S4Dap, C16Pen] can be used for the study of neuropathic pain .
    Mr1.1[S4Dap, C16Pen]
  • HY-P11470
    Conofurin-Delta

    		nAChR SARS-CoV Infection
    Conofurin-Delta is a potent α7 nAChR inhibitor with an IC50 of 177 nM. Conofurin-Delta also inhibits α9α10 nAChR with an IC50 of 98.1 nM. Conofurin-Delta may be used in SARS-CoV-2 infection research .
    Conofurin-Delta
  • HY-N16997
    (+)-Phyllocladene

    [5α,9α,10β,(+)]-Kaur-16-ene

    		 Drug Derivative Others
    (+)-Phyllocladene ([5α,9α,10β,(+)]-Kaur-16-ene) is a natural diterpene.
    (+)-Phyllocladene
  • HY-180559
    nAChR antagonist 2

    		nAChR Interleukin Related Inflammation/Immunology
    nAChR antagonist 2 is a selective nAChR antagonist. nAChR antagonist 2 inhibits nAChR subtype including hα9α10, hα9, and hα7 with IC50 values of 16.0 nM, 26.2 nM, and 336.3 nM, respectively, in Xenopus oocytes. nAChR antagonist 2 suppresses ATP-induced IL-1β release at nanomolar concentrations. nAChR antagonist 2 can be used for nonopioid analgesics and immunomodulators research .
    nAChR antagonist 2
  • HY-180400
    PAM-2

    		nAChR Calcium Channel Neurological Disease
    PAM-2 is a potent, orally active, CNS-penetrant selective α7 nAChR positive allosteric modulator (human α7 nAChR EC50: 39 μM, rat α7 nAChR EC50: 12 μM) with anti-nociceptive and anti-inflammatory activity. PAM-2 exhibits selectivity over α9α10 nAChR (IC50 = 174 μM) and CaV2.2 channel (IC50 = 89 μM). PAM-2 decreases Streptozotocin (STZ) (HY-13753)- and Oxaliplatin (HY-17371)-inducned nuroparhic pain in mice by α7 nAChR potentiation. PAM-2 can be used for the research of neuropathic pain .
    PAM-2

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