501925-31-1
501925-31-1
Chemical Structure
PNU-120596
Synonym(s): NSC 216666
- CAS No.: 501925-31-1
- Formula:C13H14ClN3O4
- Molecular Weight:311.72
IUPAC Name: 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea
InChIKey: CEIIEALEIHQDBX-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(Cl)=C(C=C1OC)OC)NC2=NOC(C)=C2
Biological Activity: PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) that can cross the blood-brain barrier, with an EC50 of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PNU-120596 | 99.49% | PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) that can cross the blood-brain barrier, with an EC50 of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research. | ||||||||||||||||||||
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References
Keywords
