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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
β-coronaviruses
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "β-coronaviruses" in MCE Product Catalog:
1
Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria .
Cat. No.: HY-163783
CAS No.: 3105428-74-5
Target:
Research Areas:
CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2, respectively. CSNK2-IN-1 has antiviral activity against beta-coronaviruses such as SARS-CoV-2 and MHV. CSNK2-IN-1 has good solubility, metabolic stability, and low cytotoxicity, but its plasma concentration in vivo decreases rapidly and is insufficient to achieve pharmacological effects. CSNK2-IN-1 can be used in the research of antiviral drug development .
Cat. No.: HY-184050
CAS No.: 1065478-52-5
MERS-CoV-IN-3 is a 3CLpro inhibitor with an IC50 of 1.7 μM against MERS-CoV 3CLpro and an IC50 of 0.2 μM against SARS-CoV 3CLpro. MERS-CoV-IN-3 functionally inhibits protease activity essential for viral replication, downregulates viral protein production, reduces the secretion of infectious viral particles, and suppresses the replication of α-coronaviruses and β-coronaviruses derived from humans and cats. MERS-CoV-IN-3 can be used in studies related to coronavirus infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
