1065478-52-5
Chemical Structure
MERS-CoV-IN-3
- CAS No.: 1065478-52-5
- Formula:C25H25ClFN3O4
- Molecular Weight:485.94
InChIKey: HXAHMXYAYHWWRI-ZCTWNQIISA-N
SMILES: O=C(NCC1)[C@@H]1C[C@@H](C=O)NC([C@@H](NC(/C=C/C2=C(C=C(C=C2)Cl)F)=O)CC3=CC=CC=C3)=O
Biological Activity: MERS-CoV-IN-3 is a 3CLpro inhibitor with an IC50 of 1.7 μM against MERS-CoV 3CLpro and an IC50 of 0.2 μM against SARS-CoV 3CLpro. MERS-CoV-IN-3 functionally inhibits protease activity essential for viral replication, downregulates viral protein production, reduces the secretion of infectious viral particles, and suppresses the replication of α-coronaviruses and β-coronaviruses derived from humans and cats. MERS-CoV-IN-3 can be used in studies related to coronavirus infections[1].
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MERS-CoV-IN-3 | MERS-CoV-IN-3 is a 3CLpro inhibitor with an IC50 of 1.7 μM against MERS-CoV 3CLpro and an IC50 of 0.2 μM against SARS-CoV 3CLpro. MERS-CoV-IN-3 functionally inhibits protease activity essential for viral replication, downregulates viral protein production, reduces the secretion of infectious viral particles, and suppresses the replication of α-coronaviruses and β-coronaviruses derived from humans and cats. MERS-CoV-IN-3 can be used in studies related to coronavirus infections. | |||||||||||||||||||||
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Keywords
