1 Result for "

(S)-Tetrahydrocolumbamine

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "(S)-Tetrahydrocolumbamine" in MCE Product Catalog:

(-)-Isocorypalmine
(-)-Isocorypalmine
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Cat. No.: HY-N0927
CAS No.: 483-34-1
Synonyms: Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine
Category:  

Alkaloids other families Monophenols Other Diseases Phenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Dopamine Receptor

(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research .
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